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Lipid Modulation
There are many products that effectively control dyslipidemia without the side effects often associated with conventional medical drugs. For elevated cholesterol, a combination of pantethine and inositol hexacotinate can demonstrate profound improvements in one month. For those patients with elevated triglyceride levels, L-Carnitine, as well as EFAs, can often solve the problem. I prefer the inositol hexanicotinate form of niacin due to its absence of the troublesome side effects of flush and liver irritation. Its mechanism of action is similar to all niacin compounds to reduce plasma triglycerides, VLDL, LDL synthesis and total cholesterol. Pantethine is the active hormone of pantethenic acid. It is considered to be one of the most important parts of coenzyme A (CoA) that transports fats to and from the cells. It has a potent effect on cholesterol as well as triglycerides. L-Carnitine is synthesized from lysine with the help of methionine. It improves triglyceride levels, total cholesterol and increases HDL. The n-3-polyunsaturated acids in large enough doses have been shown to be helpful in many studies. The DART study and most recently the GISSI study (published in The Lancet) are good examples. The role of omega-3 fatty acids are several, but recent studies report that their most profound effects may be on arrhythmogenesis as well as inflammation. The GISSI study reported a substantial decrease in cardiovascular events as a result of fish oil supplementation. I believe the study results, although impressive, would have been even more dramatic had the investigation used omega-6 fatty acids as well. In refractory cases of elevated lipids, which have failed to respond to the above regimen, consider the combination of methionine, inositol and choline in doses of 200-400 mg of each taken 3 times daily. Lipoprotein a (Lpa) is an apolipoprotein, i.e. an LDL particle, to which an additional protein is attached. Because of Lpa's similarity with plasminogen, it interferes with fibrinolysis, and of course ultimately speeds up clot formation. Several substances as shown Table 3 can be helpful. Coenzyme Q10 for example, can inhibit the Lpa receptor expression.
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