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Phytoestrogens (plant-based estrogens) may have been misnamed. Since plants do not have a liver ¨¢ plants do not produce estrogen. However, these estrogen-like compounds do occupy receptor sites on the cell that estrogen would normally occupy, giving the equivalent of a somewhat weaker dose of estrogen to the cell. They affect the cell receptors and function like estrogen and may impart some of the beneficial effects of estrogen with fewer of the side effects. Consequently, phytoestrogens will often help to relieve hot flashes and night sweats. Red clover, black cohosh and isoflavones derived from soy all show considerable estrogenic effects, including the ability to bind to estrogen receptors in a similar manner to estrogen. Many people don't realize that red clover contains ten times the amount of phytoestrogens that soy contains. While one study stated red clover showed no clear demonstrable benefit for menopausal symptoms, another study showed it does play a role in decreasing cardiovascular symptoms by alleviating reduced arterial elasticity in menopausal women. It is important to note that for women who already have risk factors for breast and uterine cancer there is controversy surrounding the safety of supplementing with phytoestrogens. Some investigators have reported in vitro data to support that certain phytoestrogens found in soy may increase the growth of breast cancer cells, while other investigators have not reported such a connection. Normally, phytoestrogens are 1/200th to 1/400th the strength of conventional hormone replacement therapy. One herb of note, Dong Quai (Angelica sinensis), is considered a supreme female herb because it tones the blood, promotes circulation and stimulates the uterus. Like soy isoflavones, Dong Quai can have estrogen-like effects and its use in patients with a history of estrogen-sensitive cancer had not been studied. Licorice (Glycyrrhiza glabra) is an important herb for menopause since it offers additional adrenal support. It is frequently used in menopausal formulas to help stabilize hormonal imbalances perhaps due to its phytosterol content. Using deglycyrrhized licorice will eliminate blood pressure elevations that may been observed with the use of licorice. |